S-nitrosoglutathione reductase alleviates morphine analgesic tolerance by restricting PKCα S-nitrosation

S-nitrosoglutathione reductase alleviates morphine analgesic tolerance by restricting PKCα S-nitrosation

Morphine, a typical opiate, is widely used for controlling pain but can lead to various side effects with long-term use, including addiction, analgesic tolerance, and hyperalgesia. At present, however, the mechanisms underlying the development of morphine analgesic tolerance are not fully understood...

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Bibliographic Details
Main Authors: Ling-Yan Su, Lijin Jiao, Qianjin Liu, Xinhua Qiao, Ting Xie, Zhiyu Ma, Min Xu, Mao-Sen Ye, Lu-Xiu Yang, Chang Chen, Yong-Gang Yao
Format: Article
Language:English
Published: Elsevier 2024-09-01
Series:Redox Biology
Subjects:
Analgesic tolerance
Morphine
PKCα
GSNOR
S-nitrosation
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231724002179

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http://www.sciencedirect.com/science/article/pii/S2213231724002179

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