Asymmetric Synthesis and Evaluation of Danshensu-Cysteine Conjugates as Novel Potential Anti-Apoptotic Drug Candidates

Asymmetric Synthesis and Evaluation of Danshensu-Cysteine Conjugates as Novel Potential Anti-Apoptotic Drug Candidates

We have previously reported that the danshensu-cysteine conjugate N-((R)-3-benzylthio-1-methoxy-1-oxo-2-propanyl)-2-acetoxy-3-(3,4-diacetoxyphenyl) propanamide (DSC) is a potent anti-oxidative and anti-apoptotic agent. Herein, we further design and asymmetrically synthesize two diastereoisomers of D...

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Bibliographic Details
Main Authors: Li-Long Pan, Jie Wang, Yao-Ling Jia, Hong-Ming Zheng, Yang Wang, Yi-Zhun Zhu
Format: Article
Language:English
Published: MDPI AG 2014-12-01
Series:International Journal of Molecular Sciences
Subjects:
Danshensu derivative
apoptosis
asymmetric synthesis
endothelial cells
Online Access:http://www.mdpi.com/1422-0067/16/1/628

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http://www.mdpi.com/1422-0067/16/1/628

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