Altered Synapse Stability in the Early Stages of Tauopathy

Altered Synapse Stability in the Early Stages of Tauopathy

Synapse loss is a key feature of dementia, but it is unclear whether synaptic dysfunction precedes degenerative phases of the disease. Here, we show that even before any decrease in synapse density, there is abnormal turnover of cortical axonal boutons and dendritic spines in a mouse model of tauopa...

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Bibliographic Details
Main Authors: Johanna S. Jackson, Jonathan Witton, James D. Johnson, Zeshan Ahmed, Mark Ward, Andrew D. Randall, Michael L. Hutton, John T. Isaac, Michael J. O’Neill, Michael C. Ashby
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Cell Reports
Subjects:
dementia
cortex
2-photon microscopy
axon
bouton
dendritic spine
neurodegeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717303303

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http://www.sciencedirect.com/science/article/pii/S2211124717303303

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