Altered Synapse Stability in the Early Stages of Tauopathy
Synapse loss is a key feature of dementia, but it is unclear whether synaptic dysfunction precedes degenerative phases of the disease. Here, we show that even before any decrease in synapse density, there is abnormal turnover of cortical axonal boutons and dendritic spines in a mouse model of tauopa...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2017-03-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124717303303 |
| _version_ | 1811268380681830400 |
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| author | Johanna S. Jackson Jonathan Witton James D. Johnson Zeshan Ahmed Mark Ward Andrew D. Randall Michael L. Hutton John T. Isaac Michael J. O’Neill Michael C. Ashby |
| author_facet | Johanna S. Jackson Jonathan Witton James D. Johnson Zeshan Ahmed Mark Ward Andrew D. Randall Michael L. Hutton John T. Isaac Michael J. O’Neill Michael C. Ashby |
| author_sort | Johanna S. Jackson |
| collection | DOAJ |
| description | Synapse loss is a key feature of dementia, but it is unclear whether synaptic dysfunction precedes degenerative phases of the disease. Here, we show that even before any decrease in synapse density, there is abnormal turnover of cortical axonal boutons and dendritic spines in a mouse model of tauopathy-associated dementia. Strikingly, tauopathy drives a mismatch in synapse turnover; postsynaptic spines turn over more rapidly, whereas presynaptic boutons are stabilized. This imbalance between pre- and post-synaptic stability coincides with reduced synaptically driven neuronal activity in pre-degenerative stages of the disease. |
| first_indexed | 2024-04-12T21:21:52Z |
| format | Article |
| id | doaj.art-c8d1c1bd56734a5daf6d3a26936978f0 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-04-12T21:21:52Z |
| publishDate | 2017-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-c8d1c1bd56734a5daf6d3a26936978f02022-12-22T03:16:17ZengElsevierCell Reports2211-12472017-03-0118133063306810.1016/j.celrep.2017.03.013Altered Synapse Stability in the Early Stages of TauopathyJohanna S. Jackson0Jonathan Witton1James D. Johnson2Zeshan Ahmed3Mark Ward4Andrew D. Randall5Michael L. Hutton6John T. Isaac7Michael J. O’Neill8Michael C. Ashby9Lilly UK, Erl Wood Manor, Windlesham, Surrey GU20 6PH, UKCentre for Synaptic Plasticity, School of Physiology, Pharmacology and Neuroscience, University of Bristol, Biomedical Sciences Building, University Walk, Bristol BS8 1TD, UKLilly UK, Erl Wood Manor, Windlesham, Surrey GU20 6PH, UKLilly UK, Erl Wood Manor, Windlesham, Surrey GU20 6PH, UKLilly UK, Erl Wood Manor, Windlesham, Surrey GU20 6PH, UKCentre for Synaptic Plasticity, School of Physiology, Pharmacology and Neuroscience, University of Bristol, Biomedical Sciences Building, University Walk, Bristol BS8 1TD, UKLilly UK, Erl Wood Manor, Windlesham, Surrey GU20 6PH, UKLilly UK, Erl Wood Manor, Windlesham, Surrey GU20 6PH, UKLilly UK, Erl Wood Manor, Windlesham, Surrey GU20 6PH, UKCentre for Synaptic Plasticity, School of Physiology, Pharmacology and Neuroscience, University of Bristol, Biomedical Sciences Building, University Walk, Bristol BS8 1TD, UKSynapse loss is a key feature of dementia, but it is unclear whether synaptic dysfunction precedes degenerative phases of the disease. Here, we show that even before any decrease in synapse density, there is abnormal turnover of cortical axonal boutons and dendritic spines in a mouse model of tauopathy-associated dementia. Strikingly, tauopathy drives a mismatch in synapse turnover; postsynaptic spines turn over more rapidly, whereas presynaptic boutons are stabilized. This imbalance between pre- and post-synaptic stability coincides with reduced synaptically driven neuronal activity in pre-degenerative stages of the disease.http://www.sciencedirect.com/science/article/pii/S2211124717303303dementiacortex2-photon microscopyaxonboutondendritic spineneurodegeneration |
| spellingShingle | Johanna S. Jackson Jonathan Witton James D. Johnson Zeshan Ahmed Mark Ward Andrew D. Randall Michael L. Hutton John T. Isaac Michael J. O’Neill Michael C. Ashby Altered Synapse Stability in the Early Stages of Tauopathy Cell Reports dementia cortex 2-photon microscopy axon bouton dendritic spine neurodegeneration |
| title | Altered Synapse Stability in the Early Stages of Tauopathy |
| title_full | Altered Synapse Stability in the Early Stages of Tauopathy |
| title_fullStr | Altered Synapse Stability in the Early Stages of Tauopathy |
| title_full_unstemmed | Altered Synapse Stability in the Early Stages of Tauopathy |
| title_short | Altered Synapse Stability in the Early Stages of Tauopathy |
| title_sort | altered synapse stability in the early stages of tauopathy |
| topic | dementia cortex 2-photon microscopy axon bouton dendritic spine neurodegeneration |
| url | http://www.sciencedirect.com/science/article/pii/S2211124717303303 |
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