Annexin A2-Mediated Plasminogen Activation in Endothelial Cells Contributes to the Proangiogenic Effect of Adenosine A2A Receptors

Annexin A2-Mediated Plasminogen Activation in Endothelial Cells Contributes to the Proangiogenic Effect of Adenosine A2A Receptors

Adenosine A2A receptor mediates the promotion of wound healing and revascularization of injured tissue, in healthy and animals with impaired wound healing, through a mechanism depending upon tissue plasminogen activator (tPA), a component of the fibrinolytic system. In order to evaluate the contribu...

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Bibliographic Details
Main Authors: María D. Valls, María Soldado, Jorge Arasa, Miguel Perez-Aso, Adrienne J. Williams, Bruce N. Cronstein, M. Antonia Noguera, M. Carmen Terencio, M. Carmen Montesinos
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Pharmacology
Subjects:
annexin A2
microvascular endothelial cells
plasminogen activator inhibitor-1
tissue plasminogen activator
urokinase plasminogen activator
adenosine receptors
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.654104/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.654104/full

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