Restoration of L-OPA1 alleviates acute ischemic stroke injury in rats via inhibiting neuronal apoptosis and preserving mitochondrial function

Restoration of L-OPA1 alleviates acute ischemic stroke injury in rats via inhibiting neuronal apoptosis and preserving mitochondrial function

Background: Ischemic stroke can induce changes in mitochondrial morphology and function. As a regulatory gene in mitochondria, optic atrophy 1 (OPA1) plays a pivotal role in the regulation of mitochondrial dynamics and other related functions. However, its roles in cerebral ischemia-related conditio...

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Bibliographic Details
Main Authors: Yongxing Lai, Peiqiang Lin, Manli Chen, Yixian Zhang, Jianhao Chen, Mouwei Zheng, Ji Liu, Houwei Du, Ronghua Chen, Xiaodong Pan, Nan Liu, Hongbin Chen
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Redox Biology
Subjects:
OPA1
Ischemia/reperfusion
Mitochondria function
Apoptosis
Oxidative stress
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231719315083

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http://www.sciencedirect.com/science/article/pii/S2213231719315083

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