In Silico Evaluation of Coding and Non-Coding nsSNPs in the Thrombopoietin Receptor (<i>MPL</i>) Proto-Oncogene: Assessing Their Influence on Protein Stability, Structure, and Function

In Silico Evaluation of Coding and Non-Coding nsSNPs in the Thrombopoietin Receptor (<i>MPL</i>) Proto-Oncogene: Assessing Their Influence on Protein Stability, Structure, and Function

The thrombopoietin receptor (<i>MPL</i>) gene is a critical regulator of hematopoiesis, and any alterations in its structure or function can result in a range of hematological disorders. Non-synonymous single nucleotide polymorphisms (nsSNPs) in <i>MPL</i> have the potential...

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Bibliographic Details
Main Authors: Hakeemah H. Al-nakhle, Hind S. Yagoub, Sadin H. Anbarkhan, Ghadah A. Alamri, Norah M. Alsubaie
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Current Issues in Molecular Biology
Subjects:
nsSNPs
<i>MPL</i>
hematopoiesis
hematological disorders
in silico analysis
protein structure and function
Online Access:https://www.mdpi.com/1467-3045/45/12/589

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https://www.mdpi.com/1467-3045/45/12/589

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