Mutation of Pseudomonas aeruginosa lasI/rhlI diminishes its cytotoxicity, oxidative stress, inflammation, and apoptosis on THP-1 macrophages

Mutation of Pseudomonas aeruginosa lasI/rhlI diminishes its cytotoxicity, oxidative stress, inflammation, and apoptosis on THP-1 macrophages

ABSTRACT The management of Pseudomonas aeruginosa (P. aeruginosa) infections presents a substantial challenge to clinics and public health, emphasizing the urgent need for innovative strategies to address this issue. Quorum sensing (QS) is an intercellular communication mechanism that coordinates ba...

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Bibliographic Details
Main Authors: Yanying Ren, Xiaojuan You, Rui Zhu, Dengzhou Li, Chunxia Wang, Zhiqiang He, Yue Hu, Yifan Li, Xinwei Liu, Yongwei Li
Format: Article
Language:English
Published: American Society for Microbiology 2024-10-01
Series:Microbiology Spectrum
Subjects:
Pseudomonas aeruginosa
quorum sensing
oxidative stress
inflammation
apoptosis
macrophages
Online Access:https://journals.asm.org/doi/10.1128/spectrum.04146-23

Internet

https://journals.asm.org/doi/10.1128/spectrum.04146-23

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