Trypanosoma brucei Secreted Aromatic Ketoacids Activate the Nrf2/HO-1 Pathway and Suppress Pro-inflammatory Responses in Primary Murine Glia and Macrophages

Trypanosoma brucei Secreted Aromatic Ketoacids Activate the Nrf2/HO-1 Pathway and Suppress Pro-inflammatory Responses in Primary Murine Glia and Macrophages

African trypanosomes, such as Trypanosoma brucei (T. brucei), are protozoan parasites of the mammalian vasculature and central nervous system that are best known for causing fatal human sleeping sickness. As exclusively extracellular parasites, trypanosomes are subject to constant challenge from hos...

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Bibliographic Details
Main Authors: Nicole K. Campbell, David G. Williams, Hannah K. Fitzgerald, Paul J. Barry, Clare C. Cunningham, Derek P. Nolan, Aisling Dunne
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Immunology
Subjects:
trypanosomes
keto acids
immune suppression
macrophages
glia
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02137/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02137/full

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