O‐GlcNAcylation Mediates Glucose‐Induced Alterations in Endothelial Cell Phenotype in Human Diabetes Mellitus

O‐GlcNAcylation Mediates Glucose‐Induced Alterations in Endothelial Cell Phenotype in Human Diabetes Mellitus

Background Posttranslational protein modification with O‐linked N‐acetylglucosamine (O‐GlcNAc) is linked to high glucose levels in type 2 diabetes mellitus (T2DM) and may alter cellular function. We sought to elucidate the involvement of O‐GlcNAc modification in endothelial dysfunction in patients w...

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Bibliographic Details
Main Authors: Nobuyuki Masaki, Bihua Feng, Rosa Bretón‐Romero, Elica Inagaki, Robert M. Weisbrod, Jessica L. Fetterman, Naomi M. Hamburg
Format: Article
Language:English
Published: Wiley 2020-06-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
diabetes mellitus
endothelial nitric oxide synthase
insulin resistance
O‐GlcNAc
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.119.014046

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.119.014046

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