Augmentation of BMP Signaling in Cranial Neural Crest Cells Leads to Premature Cranial Sutures Fusion through Endochondral Ossification in Mice

Augmentation of BMP Signaling in Cranial Neural Crest Cells Leads to Premature Cranial Sutures Fusion through Endochondral Ossification in Mice

ABSTRACT Craniosynostosis is a congenital anomaly characterized by the premature fusion of cranial sutures. Sutures are a critical connective tissue that regulates bone growth; their aberrant fusion results in abnormal shapes of the head and face. The molecular and cellular mechanisms have been inve...

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Bibliographic Details
Main Authors: Hiroki Ueharu, Haichun Pan, Xia Liu, Mamoru Ishii, Jessica Pongetti, Anshul K. Kulkarni, Folasade E. Adegbenro, Jaden Wurn, Robert E. Maxson, Hongchen Sun, Yoshihiro Komatsu, Honghao Zhang, Jingwen Yang, Yuji Mishina
Format: Article
Language:English
Published: Wiley 2023-04-01
Series:JBMR Plus
Subjects:
BMP SIGNALING
CELL FATE
CRANIOSYNOSTOSIS
P0‐Cre
Wnt1‐Cre
Online Access:https://doi.org/10.1002/jbm4.10716

Internet

https://doi.org/10.1002/jbm4.10716

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