Persistent T cell proliferation and MDSCs expansion precede incomplete CD4+ T cell recovery in people with acute HIV-1 infection with early ART

Persistent T cell proliferation and MDSCs expansion precede incomplete CD4+ T cell recovery in people with acute HIV-1 infection with early ART

HIV-1 infection causes T cell dysfunction that cannot be fully restored by anti-retroviral therapy (ART). Myeloid-derived suppressor cells (MDSCs) expand and suppress T cell function during viral infection. In this study, we evaluated the dynamics of phenotypes and function of T cells and MDSCs and...

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Bibliographic Details
Main Authors: Zhen Li, Ping Yan, Rui Wang, Xiaofan Lu, Yang Zhang, Bin Su, Xin Zhang, Lin Yuan, Zhiying Liu, Wei Jiang, Tong Zhang, Hao Wu, Xiaojie Huang
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Heliyon
Subjects:
Acute HIV-1 infection
T cell proliferation
MDSCs
Early ART
Immune reconstitution
Immune activation
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023027974

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http://www.sciencedirect.com/science/article/pii/S2405844023027974

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