NAD+ exhaustion by CD38 upregulation contributes to blood pressure elevation and vascular damage in hypertension

NAD+ exhaustion by CD38 upregulation contributes to blood pressure elevation and vascular damage in hypertension

Abstract Hypertension is characterized by endothelial dysfunction and arterial stiffness, which contribute to the pathogenesis of atherosclerotic cardiovascular diseases. Nicotinamide adenine dinucleotide (NAD+) is an indispensable cofactor in all living cells that is involved in fundamental biologi...

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Bibliographic Details
Main Authors: Yumin Qiu, Shiyue Xu, Xi Chen, Xing Wu, Zhe Zhou, Jianning Zhang, Qiang Tu, Bing Dong, Zhefu Liu, Jiang He, Xiaoyu Zhang, Shuangshuang Liu, Chen Su, Hui Huang, Wenhao Xia, Jun Tao
Format: Article
Language:English
Published: Nature Publishing Group 2023-09-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-023-01577-3

Internet

https://doi.org/10.1038/s41392-023-01577-3

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