Downregulation of miR-223 promotes HMGB2 expression and induces oxidative stress to activate JNK and promote autophagy in an in vitro model of acute lung injury

Downregulation of miR-223 promotes HMGB2 expression and induces oxidative stress to activate JNK and promote autophagy in an in vitro model of acute lung injury

Abstract Background Excessive autophagic activity in alveolar epithelial cells is one of the main causes of acute lung injury (ALI), but the underlying molecular mechanism has not been fully elucidated. Previous studies have shown that microRNAs (miRs) are involved in regulating autophagy in several...

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Bibliographic Details
Main Authors: Hao-Yu Tan, Bei Qing, Xian-Mei Luo, Heng-Xing Liang
Format: Article
Language:English
Published: BMC 2021-11-01
Series:Journal of Inflammation
Subjects:
Autophagy
HMGB2
MiR-223
Oxidative stress
JNK signalling
Online Access:https://doi.org/10.1186/s12950-021-00295-3

Internet

https://doi.org/10.1186/s12950-021-00295-3

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