Disruption of Circadian Rhythms by Ambient Light during Neurodevelopment Leads to Autistic-like Molecular and Behavioral Alterations in Adult Mice

Disruption of Circadian Rhythms by Ambient Light during Neurodevelopment Leads to Autistic-like Molecular and Behavioral Alterations in Adult Mice

Although circadian rhythms are thought to be essential for maintaining body health, the effects of chronic circadian disruption during neurodevelopment remain elusive. Here, using the “Short Day” (SD) mouse model, in which an 8 h/8 h light/dark (LD) cycle was applied from embryonic day 1 to postnata...

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Bibliographic Details
Main Authors: Kun Fang, Dong Liu, Salil S. Pathak, Bowen Yang, Jin Li, Ramanujam Karthikeyan, Owen Y. Chao, Yi-Mei Yang, Victor X. Jin, Ruifeng Cao
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Cells
Subjects:
circadian rhythm
neurodevelopmental disorder
translational control
mTOR
MAPK
autism
Online Access:https://www.mdpi.com/2073-4409/10/12/3314

Internet

https://www.mdpi.com/2073-4409/10/12/3314

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