Natural Killer T Cells Are Involved in Atherosclerotic Plaque Instability in Apolipoprotein-E Knockout Mice

Natural Killer T Cells Are Involved in Atherosclerotic Plaque Instability in Apolipoprotein-E Knockout Mice

The infiltration and activation of macrophages as well as lymphocytes within atherosclerotic lesion contribute to the pathogenesis of plaque rupture. We have demonstrated that invariant natural killer T (iNKT) cells, a unique subset of T lymphocytes that recognize glycolipid antigens, play a crucial...

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Bibliographic Details
Main Authors: Yoshinori Ohmura, Naoki Ishimori, Akimichi Saito, Takashi Yokota, Shunpei Horii, Satoshi Tokuhara, Kazuya Iwabuchi, Hiroyuki Tsutsui
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:International Journal of Molecular Sciences
Subjects:
α-galactosylceramide
apolipoprotein E knockout mice
atherosclerosis
brachiocephalic artery
macrophages
matrix metalloproteinase
Online Access:https://www.mdpi.com/1422-0067/22/22/12451

Internet

https://www.mdpi.com/1422-0067/22/22/12451

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