Osteoarthritis-Like Changes in Bardet–Biedl Syndrome Mutant Ciliopathy Mice (Bbs1M390R/M390R): Evidence for a Role of Primary Cilia in Cartilage Homeostasis and Regulation of Inflammation

Osteoarthritis-Like Changes in Bardet–Biedl Syndrome Mutant Ciliopathy Mice (Bbs1M390R/M390R): Evidence for a Role of Primary Cilia in Cartilage Homeostasis and Regulation of Inflammation

Osteoarthritis (OA) is a debilitating inflammation related disease characterized by joint pain and effusion, loss of mobility, and deformity that may result in functional joint failure and significant impact on quality of life. Once thought of as a simple “wear and tear” disease, it is now widely re...

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Bibliographic Details
Main Authors: Isaac D. Sheffield, Mercedes A. McGee, Steven J. Glenn, Da Young Baek, Joshua M. Coleman, Bradley K. Dorius, Channing Williams, Brandon J. Rose, Anthony E. Sanchez, Michael A. Goodman, John M. Daines, Dennis L. Eggett, Val C. Sheffield, Arminda Suli, David L. Kooyman
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Physiology
Subjects:
Bardet–Biedl syndrome
Bbs
osteoarthritis
primary cilia
inflammation
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.00708/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2018.00708/full

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