The Protective Effect of Edaravone on TDP-43 Plus Oxidative Stress-Induced Neurotoxicity in Neuronal Cells: Analysis of Its Neuroprotective Mechanisms Using RNA Sequencing

The Protective Effect of Edaravone on TDP-43 Plus Oxidative Stress-Induced Neurotoxicity in Neuronal Cells: Analysis of Its Neuroprotective Mechanisms Using RNA Sequencing

Edaravone is a free-radical scavenger drug that was recently approved for the treatment of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease. A pathological hallmark of ALS is the accumulation of ubiquitinated or phosphorylated aggregates of the 43-kDa transactive response DNA binding...

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Bibliographic Details
Main Authors: Aki Soejima-Kusunoki, Kinya Okada, Ryuta Saito, Kazuhiko Watabe
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Pharmaceuticals
Subjects:
edaravone
TDP-43
transcriptome
amyotrophic lateral sclerosis
Nrf2
Online Access:https://www.mdpi.com/1424-8247/15/7/842

Internet

https://www.mdpi.com/1424-8247/15/7/842

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