The Role of G-Protein-Coupled Receptor Proteolysis Site Cleavage of Polycystin-1 in Renal Physiology and Polycystic Kidney Disease

The Role of G-Protein-Coupled Receptor Proteolysis Site Cleavage of Polycystin-1 in Renal Physiology and Polycystic Kidney Disease

Polycystin-1 (PC1) plays an essential role in renal tubular morphogenesis, and PC1 dysfunction causes human autosomal dominant polycystic kidney disease. A fundamental characteristic of PC1 is post-translational modification via cleavage at the juxtamembrane GPCR proteolysis site (GPS) motif that is...

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Bibliographic Details
Main Authors: Marie Trudel, Qin Yao, Feng Qian
Format: Article
Language:English
Published: MDPI AG 2016-01-01
Series:Cells
Subjects:
polycystin
polycystic kidney disease
GAIN domain
GPS motif
cis-autoproteolysis
adhesion GPCR
Online Access:http://www.mdpi.com/2073-4409/5/1/3

Internet

http://www.mdpi.com/2073-4409/5/1/3

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