Hypomethylation of <i>CLDN4</i> Gene Promoter Is Associated with Malignant Phenotype in Urinary Bladder Cancer

Hypomethylation of <i>CLDN4</i> Gene Promoter Is Associated with Malignant Phenotype in Urinary Bladder Cancer

The tight junction (TJ) protein claudin-4 (CLDN4) is overexpressed in bladder urothelial carcinoma (BUC) and correlates with cancer progression. However, the mechanism of CLDN4 upregulation and promotion of malignant phenotype is not clear. Here, we analyzed 157 cases of BUC and investigated the hyp...

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Main Authors: Fumisato Maesaka, Masaomi Kuwada, Shohei Horii, Shingo Kishi, Rina Fujiwara-Tani, Shiori Mori, Kiyomu Fujii, Takuya Mori, Hitoshi Ohmori, Takuya Owari, Makito Miyake, Yasushi Nakai, Nobumichi Tanaka, Ujjal Kumar Bhawal, Yi Luo, Masuo Kondoh, Kiyohide Fujimoto, Hiroki Kuniyasu
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:International Journal of Molecular Sciences
Subjects:
claudin-4
promoter methylation
bladder cancer
stemness
non-tight junction claudin
Online Access:https://www.mdpi.com/1422-0067/23/12/6516

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https://www.mdpi.com/1422-0067/23/12/6516

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