Exosomal PD-L1 induces osteogenic differentiation and promotes fracture healing by acting as an immunosuppressant

Exosomal PD-L1 induces osteogenic differentiation and promotes fracture healing by acting as an immunosuppressant

A moderate inflammatory response at the early stages of fracture healing is necessary for callus formation. Over-active and continuous inflammation, however, impairs fracture healing and leads to excessive tissue damage. Adequate fracture healing could be promoted through suppression of local over-a...

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Bibliographic Details
Main Authors: Ze Lin, Yuan Xiong, Weilin Meng, Yiqiang Hu, Lili Chen, Lang Chen, Hang Xue, Adriana C. Panayi, Wu Zhou, Yun Sun, Faqi Cao, Guodong Liu, Liangcong Hu, Chenchen Yan, Xudong Xie, Chuanchuan Lin, Kaiyong Cai, Qian Feng, Bobin Mi, Guohui Liu
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2022-07-01
Series:Bioactive Materials
Subjects:
PD-L1
Exosome
Fracture healing
Hydrogel
Immunotherapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X21005065

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http://www.sciencedirect.com/science/article/pii/S2452199X21005065

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