Knockdown of Inhibitory Guanine Nucleotide Binding Protein Giα‐2 by Antisense Oligodeoxynucleotides Attenuates the Development of Hypertension and Tachycardia in Spontaneously Hypertensive Rats

Knockdown of Inhibitory Guanine Nucleotide Binding Protein Giα‐2 by Antisense Oligodeoxynucleotides Attenuates the Development of Hypertension and Tachycardia in Spontaneously Hypertensive Rats

BackgroundWe previously showed that the levels of both Giα‐2 and Giα‐3 proteins were augmented in spontaneously hypertensive rats (SHRs) before the onset of hypertension. In addition, intraperitoneal injection of pertussis toxin, which inactivates both Giα proteins, prevented the development of hype...

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Bibliographic Details
Main Authors: Yousra Ali El‐Basyuni, Yuan Li, Madhu B. Anand‐Srivastava
Format: Article
Language:English
Published: Wiley 2016-10-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
antisense
Giα‐2 proteins
Giα‐3 proteins
hypertension
oxidative stress
tachycardia
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.116.004594

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.116.004594

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