β-Sitosterol Circumvents Obesity Induced Inflammation and Insulin Resistance by down-Regulating IKKβ/NF-κB and JNK Signaling Pathway in Adipocytes of Type 2 Diabetic Rats

β-Sitosterol Circumvents Obesity Induced Inflammation and Insulin Resistance by down-Regulating IKKβ/NF-κB and JNK Signaling Pathway in Adipocytes of Type 2 Diabetic Rats

β-sitosterol (SIT), the most abundant bioactive component of vegetable oil and other plants, is a highly potent antidiabetic drug. Our previous studies show that SIT controls hyperglycemia and insulin resistance by activating insulin receptor and glucose transporter 4 (GLUT-4) in the adipocytes of o...

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Bibliographic Details
Main Authors: Selvaraj Jayaraman, Nalini Devarajan, Ponnulakshmi Rajagopal, Shyamaladevi Babu, Senthil Kumar Ganesan, Vishnu Priya Veeraraghavan, Chella Perumal Palanisamy, Bo Cui, Vijayalakshmi Periyasamy, Kirubhanand Chandrasekar
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Molecules
Subjects:
adipokines
adipose tissue
inflammation
obesity
signaling pathways
type-2 diabetes
Online Access:https://www.mdpi.com/1420-3049/26/7/2101

Internet

https://www.mdpi.com/1420-3049/26/7/2101

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