Clonal evolution in primary breast cancers under sequential epirubicin and docetaxel monotherapy

Clonal evolution in primary breast cancers under sequential epirubicin and docetaxel monotherapy

Abstract Background Subclonal evolution during primary breast cancer treatment is largely unexplored. We aimed to assess the dynamic changes in subclonal composition of treatment-naïve breast cancers during neoadjuvant chemotherapy. Methods We performed whole exome sequencing of tumor biopsies colle...

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Bibliographic Details
Main Authors: Andreas Venizelos, Christina Engebrethsen, Wei Deng, Jürgen Geisler, Stephanie Geisler, Gjertrud T. Iversen, Turid Aas, Hildegunn S. Aase, Manouchehr Seyedzadeh, Eli Sihn Steinskog, Ola Myklebost, Sigve Nakken, Daniel Vodak, Eivind Hovig, Leonardo A. Meza-Zepeda, Per E. Lønning, Stian Knappskog, Hans P. Eikesdal
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Genome Medicine
Subjects:
Breast cancer
Clonal evolution
Neoadjuvant chemotherapy
Chemoresistance
Online Access:https://doi.org/10.1186/s13073-022-01090-2

Internet

https://doi.org/10.1186/s13073-022-01090-2

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