Differential Effects of the Betablockers Carvedilol, Metoprolol and Bisoprolol on Cardiac K<sub>v</sub>4.3 (I<sub>to</sub>) Channel Isoforms

Differential Effects of the Betablockers Carvedilol, Metoprolol and Bisoprolol on Cardiac K<sub>v</sub>4.3 (I<sub>to</sub>) Channel Isoforms

Cardiac K<sub>v</sub>4.3 channels contribute to the transient outward K<sup>+</sup> current, I<sub>to</sub>, during early repolarization of the cardiac action potential. Two different isoforms of K<sub>v</sub>4.3 are present in the human ventricle and...

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Bibliographic Details
Main Authors: Ann-Kathrin Rahm, Juline Hackbarth, Mara E. Müller, Julia Pfeiffer, Heike Gampp, Finn Petersenn, Rasmus Rivinius, Norbert Frey, Patrick Lugenbiel, Dierk Thomas
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:International Journal of Molecular Sciences
Subjects:
K<sub>v</sub>4.3
I<sub>to</sub>
betablocker
antiarrhythmic effects
heart failure
Online Access:https://www.mdpi.com/1422-0067/24/18/13842

Internet

https://www.mdpi.com/1422-0067/24/18/13842

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