Identification of T cell dysfunction molecular subtypes and exploration of potential immunotherapy targets in BRAF V600E-mutant colorectal cancer

Identification of T cell dysfunction molecular subtypes and exploration of potential immunotherapy targets in BRAF V600E-mutant colorectal cancer

Abstract Background Immunotherapy is an effective treatment for BRAF V600E-mutant colorectal cancer, but currently, only a few benefit from it. Therefore, exploring new immunotherapy strategies is essential. Methods We obtained RNA sequencing data and clinical information of colorectal cancer patien...

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Bibliographic Details
Main Authors: Tiefeng Gu, Haonan Qi, Jiaqi Wang, Liangwei Sun, Yongqi Su, Hanqing Hu
Format: Article
Language:English
Published: Springer 2025-02-01
Series:Discover Oncology
Subjects:
BRAF V600E
Colorectal cancer
Molecular subtypes
Immunotherapy
Machine learning
IDO1
Online Access:https://doi.org/10.1007/s12672-025-01930-8

Internet

https://doi.org/10.1007/s12672-025-01930-8

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