β-aminoisobutyrics acid, a metabolite of BCAA, activates the AMPK/Nrf-2 pathway to prevent ferroptosis and ameliorates lung ischemia-reperfusion injury

β-aminoisobutyrics acid, a metabolite of BCAA, activates the AMPK/Nrf-2 pathway to prevent ferroptosis and ameliorates lung ischemia-reperfusion injury

Abstract Background Lung ischemia-reperfusion (I/R) injury is a serious clinical problem without effective treatment. Enhancing branched-chain amino acids (BCAA) metabolism can protect against cardiac I/R injury, which may be related to bioactive molecules generated by BCAA metabolites. L-β-aminoiso...

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Bibliographic Details
Main Authors: Ziyue Zhang, Xingbing Li, Jingwen Guo, Bo He, Lianpan Wu, Rongpei Yang, Xingyue Li, Dandong Fang, XiaoLi Yang, Donghai Yang, Fengxian Wang, Ming Tang, Yu Han, Pedro A. Jose, Hongyong Wang, Chunyu Zeng
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Molecular Medicine
Subjects:
L-BAIBA
Lung ischemia-reperfusion injury
Ferroptosis
Branched chain amino acid
Nrf-2
AMPK
Online Access:https://doi.org/10.1186/s10020-023-00729-z

Internet

https://doi.org/10.1186/s10020-023-00729-z

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