Adenosine mediates functional and metabolic suppression of peripheral and tumor-infiltrating CD8+ T cells

Adenosine mediates functional and metabolic suppression of peripheral and tumor-infiltrating CD8+ T cells

Abstract Background Several mechanisms are present in the tumor microenvironment (TME) to impair cytotoxic T cell responses potentially able to control tumor growth. Among these, the accumulation of adenosine (Ado) contributes to tumor progression and represents a promising immunotherapeutic target....

Full description

Bibliographic Details
Main Authors: Beatris Mastelic-Gavillet, Blanca Navarro Rodrigo, Laure Décombaz, Haiping Wang, Giuseppe Ercolano, Rita Ahmed, Leyder Elena Lozano, Angela Ianaro, Laurent Derré, Massimo Valerio, Thomas Tawadros, Patrice Jichlinski, Tu Nguyen-Ngoc, Daniel E. Speiser, Grégory Verdeil, Nicolas Gestermann, Olivier Dormond, Lana Kandalaft, George Coukos, Camilla Jandus, Christine Ménétrier-Caux, Christophe Caux, Ping-Chih Ho, Pedro Romero, Alexandre Harari, Selena Vigano
Format: Article
Language:English
Published: BMJ Publishing Group 2019-10-01
Series:Journal for ImmunoTherapy of Cancer
Subjects:
Adenosine
CD8 T cells
Metabolism
mTOR
TILs
Online Access:http://link.springer.com/article/10.1186/s40425-019-0719-5

Internet

http://link.springer.com/article/10.1186/s40425-019-0719-5

Similar Items