Single-cell transcriptome analysis reveals aberrant stromal cells and heterogeneous endothelial cells in alcohol-induced osteonecrosis of the femoral head

Single-cell transcriptome analysis reveals aberrant stromal cells and heterogeneous endothelial cells in alcohol-induced osteonecrosis of the femoral head

Single-cell RNA-seq of bone from patients with osteonecrosis of the femoral head (ONFH) highlights the relevance of stromal and endothelial cells to disease pathogenesis, and provides a resource for developing cell type-specific therapeutic strategies.

Bibliographic Details
Main Authors: Zheting Liao, Yu Jin, Yuhao Chu, Hansen Wu, Xiaoyu Li, Zhonghao Deng, Shuhao Feng, Nachun Chen, Ziheng Luo, Xiaoyong Zheng, Liangxiao Bao, Yongqing Xu, Hongbo Tan, Liang Zhao
Format: Article
Language:English
Published: Nature Portfolio 2022-04-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-022-03271-6

Internet

https://doi.org/10.1038/s42003-022-03271-6

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