Single-cell transcriptome analysis reveals aberrant stromal cells and heterogeneous endothelial cells in alcohol-induced osteonecrosis of the femoral head
Single-cell RNA-seq of bone from patients with osteonecrosis of the femoral head (ONFH) highlights the relevance of stromal and endothelial cells to disease pathogenesis, and provides a resource for developing cell type-specific therapeutic strategies.
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-04-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-022-03271-6 |
| _version_ | 1828263641661571072 |
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| author | Zheting Liao Yu Jin Yuhao Chu Hansen Wu Xiaoyu Li Zhonghao Deng Shuhao Feng Nachun Chen Ziheng Luo Xiaoyong Zheng Liangxiao Bao Yongqing Xu Hongbo Tan Liang Zhao |
| author_facet | Zheting Liao Yu Jin Yuhao Chu Hansen Wu Xiaoyu Li Zhonghao Deng Shuhao Feng Nachun Chen Ziheng Luo Xiaoyong Zheng Liangxiao Bao Yongqing Xu Hongbo Tan Liang Zhao |
| author_sort | Zheting Liao |
| collection | DOAJ |
| description | Single-cell RNA-seq of bone from patients with osteonecrosis of the femoral head (ONFH) highlights the relevance of stromal and endothelial cells to disease pathogenesis, and provides a resource for developing cell type-specific therapeutic strategies. |
| first_indexed | 2024-04-13T04:13:40Z |
| format | Article |
| id | doaj.art-c90447417af749898959d27eb6316b89 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-04-13T04:13:40Z |
| publishDate | 2022-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-c90447417af749898959d27eb6316b892022-12-22T03:03:03ZengNature PortfolioCommunications Biology2399-36422022-04-015111410.1038/s42003-022-03271-6Single-cell transcriptome analysis reveals aberrant stromal cells and heterogeneous endothelial cells in alcohol-induced osteonecrosis of the femoral headZheting Liao0Yu Jin1Yuhao Chu2Hansen Wu3Xiaoyu Li4Zhonghao Deng5Shuhao Feng6Nachun Chen7Ziheng Luo8Xiaoyong Zheng9Liangxiao Bao10Yongqing Xu11Hongbo Tan12Liang Zhao13Department of Orthopaedic Surgery, Nanfang Hospital, Southern Medical UniversityDepartment of Orthopaedic Surgery, Nanfang Hospital, Southern Medical UniversityDepartment of Orthopaedic Surgery, Nanfang Hospital, Southern Medical UniversityGuangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Southern Medical UniversityDepartment of Orthopaedic Surgery, Nanfang Hospital, Southern Medical UniversityDepartment of Orthopaedic Surgery, Nanfang Hospital, Southern Medical UniversityDepartment of Orthopaedic Surgery, Nanfang Hospital, Southern Medical UniversityDepartment of Orthopaedic Surgery, Nanfang Hospital, Southern Medical UniversityDepartment of Orthopaedic Surgery, Nanfang Hospital, Southern Medical UniversityOrthopaedic Department, The 8th medical center of Chinese PLA General HospitalDepartment of Orthopaedic Surgery, Nanfang Hospital, Southern Medical UniversityDepartment of Orthopaedic, The 920th Hospital of Joint Logistics Support ForceDepartment of Orthopaedic, The 920th Hospital of Joint Logistics Support ForceDepartment of Orthopaedic Surgery, Nanfang Hospital, Southern Medical UniversitySingle-cell RNA-seq of bone from patients with osteonecrosis of the femoral head (ONFH) highlights the relevance of stromal and endothelial cells to disease pathogenesis, and provides a resource for developing cell type-specific therapeutic strategies.https://doi.org/10.1038/s42003-022-03271-6 |
| spellingShingle | Zheting Liao Yu Jin Yuhao Chu Hansen Wu Xiaoyu Li Zhonghao Deng Shuhao Feng Nachun Chen Ziheng Luo Xiaoyong Zheng Liangxiao Bao Yongqing Xu Hongbo Tan Liang Zhao Single-cell transcriptome analysis reveals aberrant stromal cells and heterogeneous endothelial cells in alcohol-induced osteonecrosis of the femoral head Communications Biology |
| title | Single-cell transcriptome analysis reveals aberrant stromal cells and heterogeneous endothelial cells in alcohol-induced osteonecrosis of the femoral head |
| title_full | Single-cell transcriptome analysis reveals aberrant stromal cells and heterogeneous endothelial cells in alcohol-induced osteonecrosis of the femoral head |
| title_fullStr | Single-cell transcriptome analysis reveals aberrant stromal cells and heterogeneous endothelial cells in alcohol-induced osteonecrosis of the femoral head |
| title_full_unstemmed | Single-cell transcriptome analysis reveals aberrant stromal cells and heterogeneous endothelial cells in alcohol-induced osteonecrosis of the femoral head |
| title_short | Single-cell transcriptome analysis reveals aberrant stromal cells and heterogeneous endothelial cells in alcohol-induced osteonecrosis of the femoral head |
| title_sort | single cell transcriptome analysis reveals aberrant stromal cells and heterogeneous endothelial cells in alcohol induced osteonecrosis of the femoral head |
| url | https://doi.org/10.1038/s42003-022-03271-6 |
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