Towards Developing Novel Prostate Cancer Recurrence Suppressors: Acute Toxicity of Pseurotin A, an Orally Active PCSK9 Axis-Targeting Small-Molecule in Swiss Albino Mice

Towards Developing Novel Prostate Cancer Recurrence Suppressors: Acute Toxicity of Pseurotin A, an Orally Active PCSK9 Axis-Targeting Small-Molecule in Swiss Albino Mice

The proprotein convertase subtilisin kexin type 9 (PCSK9) emerged as a molecular target of great interest for the management of cardiovascular disorders due to its ability to reduce low density lipoprotein (LDL) cholesterol by binding and targeting at LDLR for lysosomal degradation in cells. Prelimi...

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Bibliographic Details
Main Authors: Oliver C. McGehee, Hassan Y. Ebrahim, Ashkan H. Rad, Khaldoun S. Abdelwahed, Ethar A. Mudhish, Judy A. King, Iman E. Helal, Sharon A. Meyer, Khalid A. El Sayed
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Molecules
Subjects:
proprotein convertase subtilisin/kexin type 9 (PCSK9)
pseurotin A
acute oral toxicity
Online Access:https://www.mdpi.com/1420-3049/28/3/1460

Internet

https://www.mdpi.com/1420-3049/28/3/1460

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