Assisting PNA transport through cystic fibrosis human airway epithelia with biodegradable hybrid lipid-polymer nanoparticles

Assisting PNA transport through cystic fibrosis human airway epithelia with biodegradable hybrid lipid-polymer nanoparticles

Abstract Cystic fibrosis (CF) is characterized by an airway obstruction caused by a thick mucus due to a malfunctioning Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein. The sticky mucus restricts drugs in reaching target cells limiting the efficiency of treatments. The development...

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Bibliographic Details
Main Authors: Marika Comegna, Gemma Conte, Andrea Patrizia Falanga, Maria Marzano, Gustavo Cernera, Antonella Miriam Di Lullo, Felice Amato, Nicola Borbone, Stefano D’Errico, Francesca Ungaro, Ivana d’Angelo, Giorgia Oliviero, Giuseppe Castaldo
Format: Article
Language:English
Published: Nature Portfolio 2021-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-85549-z

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https://doi.org/10.1038/s41598-021-85549-z

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