Methods for handling missing data in serially sampled sputum specimens for mycobacterial culture conversion calculation

Methods for handling missing data in serially sampled sputum specimens for mycobacterial culture conversion calculation

Abstract Background The occurrence and timing of mycobacterial culture conversion is used as a proxy for tuberculosis treatment response. When researchers serially sample sputum during tuberculosis studies, contamination or missed visits leads to missing data points. Traditionally, this is managed b...

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Bibliographic Details
Main Authors: Samantha Malatesta, Isabelle R. Weir, Sarah E. Weber, Tara C. Bouton, Tara Carney, Danie Theron, Bronwyn Myers, C. Robert Horsburgh, Robin M. Warren, Karen R. Jacobson, Laura F. White
Format: Article
Language:English
Published: BMC 2022-11-01
Series:BMC Medical Research Methodology
Subjects:
Longitudinal missing data
Multiple imputation
Survival analysis
Tuberculosis
Culture conversion
Online Access:https://doi.org/10.1186/s12874-022-01782-8

Internet

https://doi.org/10.1186/s12874-022-01782-8

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