Direct and Indirect Effect of TGFβ on Treg Transendothelial Recruitment in HCC Tissue Microenvironment

Direct and Indirect Effect of TGFβ on Treg Transendothelial Recruitment in HCC Tissue Microenvironment

The balance between anti-tumor and tumor-promoting immune cells, such as CD4+ Th1 and regulatory T cells (Tregs), respectively, is assumed to dictate the progression of hepatocellular carcinoma (HCC). The transforming growth factor beta (TGFβ) markedly shapes the HCC microenvironment, regulating the...

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Bibliographic Details
Main Authors: Francesco Dituri, Serena Mancarella, Grazia Serino, Nada Chaoul, Luigi Giovanni Lupo, Erica Villa, Isabel Fabregat, Gianluigi Giannelli
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:International Journal of Molecular Sciences
Subjects:
HCC
TGF beta
cancer immunity
regulatory T cells
cancer-associated fibroblasts
transendothelial migration
Online Access:https://www.mdpi.com/1422-0067/22/21/11765

Internet

https://www.mdpi.com/1422-0067/22/21/11765

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