Decreased PPARgamma in the trigeminal spinal subnucleus caudalis due to neonatal injury contributes to incision-induced mechanical allodynia in female rats

Abstract Whisker pad skin incision in infancy causes the prolongation of mechanical allodynia after re-incision in adulthood. A recent study also proposed the importance of sex differences in pain signaling in the spinal cord. However, the sex difference in re-incision-induced mechanical allodynia i...

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Bibliographic Details
Main Authors: Jo Otsuji, Yoshinori Hayashi, Suzuro Hitomi, Chihiro Soma, Kumi Soma, Ikuko Shibuta, Koichi Iwata, Tetsuo Shirakawa, Masamichi Shinoda
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-23832-3