Molecular features of luminal breast cancer defined through spatial and single‐cell transcriptomics

Molecular features of luminal breast cancer defined through spatial and single‐cell transcriptomics

Abstract Background Intratumour heterogeneity is a hallmark of most solid tumours, including breast cancers. We applied spatial transcriptomics and single‐cell RNA‐sequencing on patient‐derived xenografts (PDXs) to profile spatially resolved cell populations within oestrogen receptor‐positive (ER+)...

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Bibliographic Details
Main Authors: Ryohei Yoshitake, Hitomi Mori, Desiree Ha, Xiwei Wu, Jinhui Wang, Xiaoqiang Wang, Kohei Saeki, Gregory Chang, Hyun Jeong Shim, Yin Chan, Shiuan Chen
Format: Article
Language:English
Published: Wiley 2024-01-01
Series:Clinical and Translational Medicine
Subjects:
breast cancer
oestrogen receptor
intratumour heterogeneity
single‐cell RNA‐sequencing
spatial transcriptomics
Online Access:https://doi.org/10.1002/ctm2.1548

Internet

https://doi.org/10.1002/ctm2.1548

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