The unfolded protein response in fission yeast modulates stability of select mRNAs to maintain protein homeostasis

The unfolded protein response in fission yeast modulates stability of select mRNAs to maintain protein homeostasis

The unfolded protein response (UPR) monitors the protein folding capacity of the endoplasmic reticulum (ER). In all organisms analyzed to date, the UPR drives transcriptional programs that allow cells to cope with ER stress. The non-conventional splicing of Hac1 (yeasts) and XBP1 (metazoans) mRNA, e...

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Bibliographic Details
Main Authors: Philipp Kimmig, Marcy Diaz, Jiashun Zheng, Christopher C Williams, Alexander Lang, Tomas Aragón, Hao Li, Peter Walter
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2012-10-01
Series:eLife
Subjects:
Unfolded Protein Response
Ire1
selective mRNA decay
Bip1 mRNA stabilization
ER homeostasis
Online Access:https://elifesciences.org/articles/00048

Internet

https://elifesciences.org/articles/00048

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