7-Acetoxycoumarin Inhibits LPS-Induced Inflammatory Cytokine Synthesis by IκBα Degradation and MAPK Activation in Macrophage Cells

7-Acetoxycoumarin Inhibits LPS-Induced Inflammatory Cytokine Synthesis by IκBα Degradation and MAPK Activation in Macrophage Cells

Acetylation involves the chemical introduction of an acetyl group in place of an active hydrogen group into a compound. In this study, we synthesized 7-acetoxycoumarin (7AC) from acetylation of umbelliferone (UMB). We examined the anti-inflammatory properties of 7AC in lipopolysaccharide (LPS)-treat...

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Bibliographic Details
Main Authors: Taejin Park, Jin-Soo Park, Ji Han Sim, Seung-Young Kim
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Molecules
Subjects:
7-acetoxycoumarin
umbelliferone
anti-inflammatory
acetylation
phosphorylation
Online Access:https://www.mdpi.com/1420-3049/25/14/3124

Internet

https://www.mdpi.com/1420-3049/25/14/3124

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