Cellular Immune Response Induced by DNA Immunization of Mice with Drug Resistant Integrases of HIV-1 Clade A Offers Partial Protection against Growth and Metastatic Activity of Integrase-Expressing Adenocarcinoma Cells

Cellular Immune Response Induced by DNA Immunization of Mice with Drug Resistant Integrases of HIV-1 Clade A Offers Partial Protection against Growth and Metastatic Activity of Integrase-Expressing Adenocarcinoma Cells

Therapeutic DNA-vaccination against drug-resistant HIV-1 may hinder emergence and spread of drug-resistant HIV-1, allowing for longer successful antiretroviral treatment (ART) up-to relief of ART. We designed DNA-vaccines against drug-resistant HIV-1 based on consensus clade A integrase (IN) resista...

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Bibliographic Details
Main Authors: Maria Isaguliants, Olga Krotova, Stefan Petkov, Juris Jansons, Ekaterina Bayurova, Dzeina Mezale, Ilze Fridrihsone, Athina Kilpelainen, Philip Podschwadt, Yulia Agapkina, Olga Smirnova, Linda Kostic, Mina Saleem, Oleg Latyshev, Olesja Eliseeva, Anastasia Malkova, Tatiana Gorodnicheva, Britta Wahren, Ilya Gordeychuk, Elizaveta Starodubova, Anastasia Latanova
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Microorganisms
Subjects:
HIV-1
ART
therapeutic DNA vaccine
integrase
immunotoxicity
T-cell response
Online Access:https://www.mdpi.com/2076-2607/9/6/1219

Internet

https://www.mdpi.com/2076-2607/9/6/1219

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