Intranasal administration of a single dose of MVA-based vaccine candidates against COVID-19 induced local and systemic immune responses and protects mice from a lethal SARS-CoV-2 infection

Intranasal administration of a single dose of MVA-based vaccine candidates against COVID-19 induced local and systemic immune responses and protects mice from a lethal SARS-CoV-2 infection

Current coronavirus disease-19 (COVID-19) vaccines are administered by the intramuscular route, but this vaccine administration failed to prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus infection in the upper respiratory tract, mainly due to the absence of virus-specific m...

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Bibliographic Details
Main Authors: Patricia Pérez, David Astorgano, Guillermo Albericio, Sara Flores, Pedro J. Sánchez-Cordón, Joanna Luczkowiak, Rafael Delgado, José M. Casasnovas, Mariano Esteban, Juan García-Arriaza
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV-2
vaccine candidates
MVA
S protein
intranasal delivery
immunogenicity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.995235/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.995235/full

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