Metformin Protects Against Diabetes-Induced Cognitive Dysfunction by Inhibiting Mitochondrial Fission Protein DRP1

Metformin Protects Against Diabetes-Induced Cognitive Dysfunction by Inhibiting Mitochondrial Fission Protein DRP1

Objectives: Diabetes is an independent risk factor for dementia. Mitochondrial dysfunction is a critical player in diabetes and diabetic complications. The present study aimed to investigate the role of mitochondrial dynamic changes in diabetes-associated cognitive impairment.Methods: Cognitive func...

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Bibliographic Details
Main Authors: Yan Hu, Yile Zhou, Yajie Yang, Haihong Tang, Yuan Si, Zhouyi Chen, Yi Shi, Hao Fang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Pharmacology
Subjects:
diabetes
cognitive dysfunction
mitochondrial fission
dynamin-related protein 1
reactive oxidative stress
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.832707/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.832707/full

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