Inhibition of ubiquitin‐specific protease 2 causes accumulation of reactive oxygen species, mitochondria dysfunction, and intracellular ATP decrement in C2C12 myoblasts

Inhibition of ubiquitin‐specific protease 2 causes accumulation of reactive oxygen species, mitochondria dysfunction, and intracellular ATP decrement in C2C12 myoblasts

Abstract Ubiquitin‐specific protease 2 (USP2) is considered to participate in the differentiation of myoblasts to myotubes, however, its functions in myoblasts under growth conditions remain elusive. In this study, we analyzed the physiological roles of USP2 in myoblasts using Usp2 knockout (KO) C2C...

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Bibliographic Details
Main Authors: Mayuko Hashimoto, Natsuko Saito, Haru Ohta, Kumiko Yamamoto, Asuka Tashiro, Kosuke Nakazawa, Osamu Inanami, Hiroshi Kitamura
Format: Article
Language:English
Published: Wiley 2019-07-01
Series:Physiological Reports
Subjects:
USP
myoblast
mitochondria
respiratory chain
oxidative phosphorylation
Online Access:https://doi.org/10.14814/phy2.14193

Internet

https://doi.org/10.14814/phy2.14193

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