Base preference for inosine 3′-riboendonuclease activity of human endonuclease V: implications for cleavage of poly-A tails containing inosine

Base preference for inosine 3′-riboendonuclease activity of human endonuclease V: implications for cleavage of poly-A tails containing inosine

Abstract Deamination of bases is a form of DNA damage that occurs spontaneously via the hydrolysis and nitrosation of living cells, generating hypoxanthine from adenine. E. coli endonuclease V (eEndoV) cleaves hypoxanthine-containing double-stranded DNA, whereas human endonuclease V (hEndoV) cleaves...

Täydet tiedot

Bibliografiset tiedot
Päätekijät: Kazuma Mitsuoka, Jung In Kim, Aya Yoshida, Akane Matsumoto, Narumi Aoki-Shioi, Shigenori Iwai, Isao Kuraoka
Aineistotyyppi: Artikkeli
Kieli:English
Julkaistu: Nature Portfolio 2024-06-01
Sarja:Scientific Reports
Aiheet:
Deamination
Endonuclease V
Inosine
DNA repair
RNA editing
Poly-A tail
Linkit:https://doi.org/10.1038/s41598-024-65814-7

Internet

https://doi.org/10.1038/s41598-024-65814-7

Samankaltaisia teoksia