Current status and prospects of antitumor nucleoside agents whose activities are mediated by deoxycytidine kinase(脱氧胞苷激酶介导的核苷类似物抗肿瘤药物的现状及前景)

ara-C，CNDAC等核苷类似物药物通过与DNA链的结合，抑制DNA合成，导致细胞死亡，从而发挥其抗肿瘤活性.它们的活化必须借助于脱氧胞苷激酶的磷酸化作用.本文介绍了此类药物的细胞毒性机制和药物抗性机制的研究进展，并对其发展前景进行了展望....

Bibliographic Details
Main Authors:	HANNing(韩凝), MINGZheng-huan(明镇寰), ZHUMu-yuan(朱睦元)
Format:	Article
Language:	zho
Published:	Zhejiang University Press 2001-09-01
Series:	Zhejiang Daxue xuebao. Lixue ban
Subjects:	核苷类似物抗肿瘤药物
Online Access:	https://doi.org/zjup/1008-9497.2001.28.5.567-571

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