Current status and prospects of antitumor nucleoside agents whose activities are mediated by deoxycytidine kinase(脱氧胞苷激酶介导的核苷类似物抗肿瘤药物的现状及前景)
ara-C，CNDAC等核苷类似物药物通过与DNA链的结合，抑制DNA合成，导致细胞死亡，从而发挥其抗肿瘤活性.它们的活化必须借助于脱氧胞苷激酶的磷酸化作用.本文介绍了此类药物的细胞毒性机制和药物抗性机制的研究进展，并对其发展前景进行了展望....
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | zho |
| Published: |
Zhejiang University Press
2001-09-01
|
| Series: | Zhejiang Daxue xuebao. Lixue ban |
| Subjects: | |
| Online Access: | https://doi.org/zjup/1008-9497.2001.28.5.567-571 |
| _version_ | 1797236518093324288 |
|---|---|
| author | HANNing(韩凝) MINGZheng-huan(明镇寰) ZHUMu-yuan(朱睦元) |
| author_facet | HANNing(韩凝) MINGZheng-huan(明镇寰) ZHUMu-yuan(朱睦元) |
| author_sort | HANNing(韩凝) |
| collection | DOAJ |
| description | ara-C，CNDAC等核苷类似物药物通过与DNA链的结合，抑制DNA合成，导致细胞死亡，从而发挥其抗肿瘤活性.它们的活化必须借助于脱氧胞苷激酶的磷酸化作用.本文介绍了此类药物的细胞毒性机制和药物抗性机制的研究进展，并对其发展前景进行了展望. |
| first_indexed | 2024-04-24T17:05:07Z |
| format | Article |
| id | doaj.art-c92969186fd14a0ca8c60b9066f10f9b |
| institution | Directory Open Access Journal |
| issn | 1008-9497 |
| language | zho |
| last_indexed | 2024-04-24T17:05:07Z |
| publishDate | 2001-09-01 |
| publisher | Zhejiang University Press |
| record_format | Article |
| series | Zhejiang Daxue xuebao. Lixue ban |
| spelling | doaj.art-c92969186fd14a0ca8c60b9066f10f9b2024-03-29T01:58:17ZzhoZhejiang University PressZhejiang Daxue xuebao. Lixue ban1008-94972001-09-01285567571zjup/1008-9497.2001.28.5.567-571Current status and prospects of antitumor nucleoside agents whose activities are mediated by deoxycytidine kinase(脱氧胞苷激酶介导的核苷类似物抗肿瘤药物的现状及前景)HANNing(韩凝)0MINGZheng-huan(明镇寰)1ZHUMu-yuan(朱睦元)2College of Life Science, Zhejiang University, Hangzhou 310028, China(浙江大学生命科学学院，浙江 杭州 310028)College of Life Science, Zhejiang University, Hangzhou 310028, China(浙江大学生命科学学院，浙江 杭州 310028)College of Life Science, Zhejiang University, Hangzhou 310028, China(浙江大学生命科学学院，浙江 杭州 310028)ara-C，CNDAC等核苷类似物药物通过与DNA链的结合，抑制DNA合成，导致细胞死亡，从而发挥其抗肿瘤活性.它们的活化必须借助于脱氧胞苷激酶的磷酸化作用.本文介绍了此类药物的细胞毒性机制和药物抗性机制的研究进展，并对其发展前景进行了展望.https://doi.org/zjup/1008-9497.2001.28.5.567-571核苷类似物抗肿瘤药物 |
| spellingShingle | HANNing(韩凝) MINGZheng-huan(明镇寰) ZHUMu-yuan(朱睦元) Current status and prospects of antitumor nucleoside agents whose activities are mediated by deoxycytidine kinase(脱氧胞苷激酶介导的核苷类似物抗肿瘤药物的现状及前景) Zhejiang Daxue xuebao. Lixue ban 核苷类似物 抗肿瘤药物 |
| title | Current status and prospects of antitumor nucleoside agents whose activities are mediated by deoxycytidine kinase(脱氧胞苷激酶介导的核苷类似物抗肿瘤药物的现状及前景) |
| title_full | Current status and prospects of antitumor nucleoside agents whose activities are mediated by deoxycytidine kinase(脱氧胞苷激酶介导的核苷类似物抗肿瘤药物的现状及前景) |
| title_fullStr | Current status and prospects of antitumor nucleoside agents whose activities are mediated by deoxycytidine kinase(脱氧胞苷激酶介导的核苷类似物抗肿瘤药物的现状及前景) |
| title_full_unstemmed | Current status and prospects of antitumor nucleoside agents whose activities are mediated by deoxycytidine kinase(脱氧胞苷激酶介导的核苷类似物抗肿瘤药物的现状及前景) |
| title_short | Current status and prospects of antitumor nucleoside agents whose activities are mediated by deoxycytidine kinase(脱氧胞苷激酶介导的核苷类似物抗肿瘤药物的现状及前景) |
| title_sort | current status and prospects of antitumor nucleoside agents whose activities are mediated by deoxycytidine kinase 脱氧胞苷激酶介导的核苷类似物抗肿瘤药物的现状及前景 |
| topic | 核苷类似物 抗肿瘤药物 |
| url | https://doi.org/zjup/1008-9497.2001.28.5.567-571 |
| work_keys_str_mv | AT hanninghánníng currentstatusandprospectsofantitumornucleosideagentswhoseactivitiesaremediatedbydeoxycytidinekinasetuōyǎngbāogānjīméijièdǎodehégānlèishìwùkàngzhǒngliúyàowùdexiànzhuàngjíqiánjǐng AT mingzhenghuanmíngzhènhuán currentstatusandprospectsofantitumornucleosideagentswhoseactivitiesaremediatedbydeoxycytidinekinasetuōyǎngbāogānjīméijièdǎodehégānlèishìwùkàngzhǒngliúyàowùdexiànzhuàngjíqiánjǐng AT zhumuyuanzhūmùyuán currentstatusandprospectsofantitumornucleosideagentswhoseactivitiesaremediatedbydeoxycytidinekinasetuōyǎngbāogānjīméijièdǎodehégānlèishìwùkàngzhǒngliúyàowùdexiànzhuàngjíqiánjǐng |