Patient-derived enteroids provide a platform for the development of therapeutic approaches in microvillus inclusion disease

Patient-derived enteroids provide a platform for the development of therapeutic approaches in microvillus inclusion disease

Microvillus inclusion disease (MVID), caused by loss-of-function mutations in the motor protein myosin Vb (MYO5B), is a severe infantile disease characterized by diarrhea, malabsorption, and acid/base instability, requiring intensive parenteral support for nutritional and fluid management. Human pat...

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Bibliographic Details
Main Authors: Meri Kalashyan, Krishnan Raghunathan, Haley Oller, Marie-Theres Bayer, Lissette Jimenez, Joseph T. Roland, Elena Kolobova, Susan J. Hagen, Jeffrey D. Goldsmith, Mitchell D. Shub, James R. Goldenring, Izumi Kaji, Jay R. Thiagarajah
Format: Article
Language:English
Published: American Society for Clinical Investigation 2023-10-01
Series:The Journal of Clinical Investigation
Subjects:
Gastroenterology
Online Access:https://doi.org/10.1172/JCI169234

Internet

https://doi.org/10.1172/JCI169234

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