Distinct mechanism of cervical cancer cell death caused by the investigational new drug SHetA2

Distinct mechanism of cervical cancer cell death caused by the investigational new drug SHetA2

Drug-targetable vulnerabilities of cancer cells include their dependence on heat shock proteins (HSPs) to support elevated mitochondrial metabolism and counteract cell death factors. The investigational new drug SHetA2 targets these vulnerabilities in ovarian and endometrial cancer cells by disrupti...

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Bibliographic Details
Main Authors: Rajani Rai, Vishal Chandra, Amy L. Kennedy, Rosemary E. Zuna, Doris Mangiaracina Benbrook
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Oncology
Subjects:
cervical cancer
SHetA2
mitochondria
mitophagy
apoptosis inducing factor
heat shock cognate 70
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.958536/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.958536/full

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