Molecular Mechanisms in the Pathogenesis of Alzheimer’s disease and Tauopathies-Prion-Like Seeded Aggregation and Phosphorylation
Neurofibrillary tau pathology (tangles and threads) and extracellular amyloid-β (Aβ) pathology are defining features of Alzheimer’s disease. For 25 years, most research has focused on the amyloid hypothesis of AD pathogenesis and progression. But, because of failures in clinical trials of Aβ-targete...
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-04-01
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| Series: | Biomolecules |
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| Online Access: | http://www.mdpi.com/2218-273X/6/2/24 |