Salt-inducible kinase inhibition promotes the adipocyte thermogenic program and adipose tissue browning

Salt-inducible kinase inhibition promotes the adipocyte thermogenic program and adipose tissue browning

Objective: Norepinephrine stimulates the adipose tissue thermogenic program through a β-adrenergic receptor (βAR)–cyclic adenosine monophosphate (cAMP)–protein kinase A (PKA) signaling cascade. We discovered that a noncanonical activation of the mechanistic target of rapamycin complex 1 (mTORC1) by...

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Bibliographic Details
Main Authors: Fubiao Shi, Flaviane de Fatima Silva, Dianxin Liu, Hari U. Patel, Jonathan Xu, Wei Zhang, Clara Türk, Marcus Krüger, Sheila Collins
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Molecular Metabolism
Subjects:
Salt-inducible kinase
SIK3
mTORC1
Adipocyte
Thermogenesis
UCP1
Online Access:http://www.sciencedirect.com/science/article/pii/S221287782300087X

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http://www.sciencedirect.com/science/article/pii/S221287782300087X

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