The Mithralog EC-7072 Induces Chronic Lymphocytic Leukemia Cell Death by Targeting Tonic B-Cell Receptor Signaling

The Mithralog EC-7072 Induces Chronic Lymphocytic Leukemia Cell Death by Targeting Tonic B-Cell Receptor Signaling

B-cell receptor (BCR)-dependent signaling is central for leukemia B-cell homeostasis, as underscored by the promising clinical results obtained in patients with chronic lymphocytic leukemia (CLL) treated with novel agents targeting components of this pathway. Herein, we demonstrate that the mithralo...

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Bibliographic Details
Main Authors: Seila Lorenzo-Herrero, Christian Sordo-Bahamonde, Gabriel Bretones, Ángel R. Payer, Ana P. González-Rodríguez, Esther González-García, Jhudit Pérez-Escuredo, Mónica Villa-Álvarez, Luz-Elena Núñez, Francisco Morís, Segundo Gonzalez, Alejandro López-Soto
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Immunology
Subjects:
CLL
apoptosis
BCR
mithralog
EC-7072
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02455/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02455/full

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